Transformational changes in the teaching of the discipline “Theoretical basis of the synthesis and relationship between the structure and action of medicines” in the conditions of today’s challenges

O.V. WELCHYNSKA

doi:10.38014/osvita.2023.92.01

Autor

O.V. WELCHYNSKA O.O. Bogomolets National Medical University, Kyiv, Ukraine https://orcid.org/0000-0001-7023-8493

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https://doi.org/10.38014/osvita.2023.92.01

Słowa kluczowe:

pharmacophores, bioisosteres, computer prediction, 5-fluorouracil, scaffold

Abstrakt

The trends of modern events and changes in the life of Ukrainian society impose new demands on the Ukrainian education system. The military aggression against Ukraine led to many problems in the field of education, the solution of which requires immediate changes in the strategy, structure, and teaching methods. It is especially difficult to convey scientific material to students about the peculiarities of the relationship “chemical structure - biological activity” and the principles of finding new biologically active substances (BAS) in the conditions of distance or dual forms of education without access to laboratory equipment and performing a practical experiment. Special computer forecasting programs come to the teacher’s aid, which allow not only to investigate the peculiarities of the chemical structure of a molecule in 2D and 3D formats, but also to obtain a forecast regarding potential biotargets and pharmacological properties of the studied chemical objects.

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